Blog

The history of steroids

Where did you first learn about steroid drugs?

In the network you can find a lot of information about the appearance of steroid drugs. Some sources claim that the drugs were originally created to correct the problems of testosterone deficiency, while the rest of the reports that the drugs were specifically designed to improve the physical performance of athletes.

Most resources report that the first information about steroids appeared in 1849, at the time when the need came to improve the human body to achieve specific results in sports. Moreover, some sources say that the first drugs appeared a little later, namely, in 1929. And yet, how did the first preparations of sports pharmacology actually appear?

And those and other sources are right. In 1849, the famous scientist Berthold took the first step in studying the effects of the male hormone testosterone on the body of an animal. Thanks to his discovery, attempts were made to search for testosterone in its pure form. After a number of failures, it was possible to create a drug with a fairly strong anabolic effect.

The first concept of doping appeared in the English dictionary in 1889. It was then that began to use drugs that allow to increase the endurance of race horses. Approximately at the same time the first attempts were made to create drugs affecting the athlete’s power indicators.

The first impetus to the emergence of drugs that improve stamina and strength was produced in ancient Greece. Even then, athletes invented a mass of methods in order to increase endurance and strength. Official statements on the creation of stimulant drugs were recorded in the early 19th century. In those days, many cyclists took a heroin-cocaine mixture to increase stamina. However, such experiments ended pitifully, when one of the competitors died right in the championship. The search for drugs to increase physical indicators resumed with a new force.

Already in 1889, scientists were able to trace the effects on the human body of testosterone, and offer it as one of the possible drugs of sports pharmacology. Soon, in 1935, the formula of testosterone by the French scientist Ernest Lacker was modified. At the same time, Adolf Butenant and Leopold Ruzicka, who patented the technology and won the Nobel Prize for scientific achievements, also worked on improving the properties of testosterone.

Since then, the production of the first testosterone-based drugs has been adjusted. However, there are faced with one significant problem. The drug was developed on an oily basis which did not dissolve in water, and, therefore, the drug did not have the desired effect with oral administration. Over time, the formula underwent a number of improvements and injectables began to be produced, which allowed for better results.

When did steroids find use in sports?

The first official steroid drugs appeared in 1950-1970. Even then, the first analogues of modern drugs were characterized by weak androgenic, and increased anabolic effect on the athlete’s body. Most of the drugs used for medical purposes, namely for the treatment of thermal skin lesions, diseases of the cardiovascular system, etc. After some time, the properties of drugs began to be used to accelerate the set of muscle mass and physical indicators of horses. And only then the drugs were specially developed for use by athletes.

The effect of taking steroids seriously interested Ziegler – the doctor of the American team. At the time of the championship in weightlifting, the doctor noted the high rates of athletes representing the Soviet Union. According to unconfirmed sources, Ziegler managed to meet with the doctor of the team representing the USSR and figure out the secret of high results, which in fact consisted in taking testosterone. This was the impetus for the birth of another steroid called Dianabol (methane), the effect of which was superior to the reception of pure testosterone. Ziegler began prescribing the drug to participants in the competition, and soon their performance was much higher than that of other athletes. So we have established the release of currently known steroids.

But, it is impossible not to note the fact that taking steroids to athletes participating in the Olympics and similar championships was already banned. If doping control showed high testosterone levels in the blood, then the athlete could be disqualified for the entire period of the competition. However, now the prohibitions do not interfere with the use of the drug in bodybuilding, and other sports. Every year there are new drugs, and the number of athletes taking steroid drugs is increasing every year.

When did steroids gain popularity in the sports world?

Craze began in the 60s. Already then Steroids began to be applied in doses much higher than therapeutic. But the main impetus in the development of sports pharmacology gave the appearance of one of the first steroids – methandrostenolone. It was he who produced and consumed in large quantities by athletes in many sports. It even came to the point that many athletes took a handful of methandrostenolone instead of traditional oatmeal. Prince Alexander de Meroda, a permanent participant in the Olympic competition, initiated the introduction of the first doping control. All participants in the competition, in whose blood steroid medication was detected, were automatically disqualified.

 

How are steroids used in medicine?

Anabolic steroids (AAS) were created to combat various ailments. People have already forgotten what the purpose of the AAS is and are concerned that they are used in sports everywhere, even chess players … But it is worth remembering what they were made of. In medicine, they are used to treat:

  • Burns;
  • Injuries of a different nature;
  • Immunodeficiency;
  • Testosterone deficiency in men (HRT);
  • To strengthen bones;
  • For the prevention of stunted growth in children;
  • Osteoporosis;
  • Arthritis;
  • Arthrosis;
  • Osteochondrosis;
  • Impotence;
  • Male menopause;
  • Infertility;
  • Oligospermia;
  • Mammary cancer.

1. HRT (hormone replacement therapy) is a condition characterized by low testosterone levels in men, for its treatment, “testosterone enanthate” or “propionate” is prescribed. This is a vital measure, because testosterone is the main hormone in the body of a man, and its decline leads to a slow wilt and weakening of the body. It is very important to maintain the physiological norms of the hormone for normal well-being and health.

2. Methandrostenolone. In treating burns, methandrostenolone is used, but its use does not end there. It is also used in the treatment of alcoholic hepatitis, diseases associated with diabetes, for injuries of various origins, degeneration, as well as for diseases when protein synthesis is difficult. As you can see, the range of application is very wide.

Human growth hormone (somatotropin) is a universal hormone and affects the cells in the body. GH is also used in all the cases mentioned above. Its main use in pediatric medicine is for growth retardation. It directly affects the height of the body at an early age. On an adult, he has no such effect. In adults, the pituitary growth zones close during maturation – this is when the bones stop growing in length.

3. Testosterone and its derivatives are, as a rule, highly androgens. It has the ability to convert to estrogen (female sex hormones). They appear in the body of a man precisely because of aromatase. In the female body, they are produced by the hatchmen. Therefore, in certain diseases such as (gynecomastia, or breast cancer), do not prescribe drugs capable of converting into estrogen. Cancer of this type is very sensitive to estrogen, and to suppress it, the level of estrogen is reduced, and drugs are taken that are incapable of conversion in case of certain injuries or diseases.

So, in the case of women, testosterone is used in breast cancer, since the androgens in the female body are not converted to estrogen, unlike the male

4. Estrogens. By the way, about estrogen – the female sex hormone, not anabolic, but for a woman it is important. As for men, testosterone, as I wrote above, is very important for the connective tissue – the joints. He, like testosterone, has a positive effect on bone tissue, strengthening it.

Note: estrogen is just as important in metabolic processes in the male body as it is in the female, it takes part in many physiological processes, and the health of the joints and ligaments also depends on them.

In short, almost all diseases originate when hormonal levels fall, and the body begins to fade, and problems with connective tissue, joints and bones begin.

Instead of the total

Androgenic steroids have side effects, it is quite natural. All drugs and substances have the flip side of the coin, the only question is what degree of complexity are side effects and how dangerous are they to health. Anabolic steroids have an effect (on the kidneys, liver, gastrointestinal tract, skin and reproductive function).

It is considered that AAS sterilizes male testicles, so my advice to you, comrades, is not to experiment, and during the course you should use contraceptives, in other words, condoms, and then your second half may be a surprise to you.

In general, the moral is – do not believe everything that they write all sorts of dubious guys. And for such characters that mislead people, situations arise – like (aerial).

Post course therapy

Speaking frankly, I didn’t really want to write on this topic. Why? First of all, because there is no single recipe for all AAC users – we are all different and the article is in any case not a direct guide to action, but only the author’s subjective view of the problem in the title. I was encouraged to write this opus, a proposal by the administration of one forum to write a small educational program on the subject of the PCT, focused mainly on beginners. So that they do not litter the forum with the same type of questions, irritating experienced “pharmacists”. “Why not?” – I thought, all some kind of benefit will be. But writing short and peremptory instructions, it seems to me in this case unproductive for the reasons stated above, the article will force a person to wiggle a little and choose the most acceptable option for themselves. Anyway, I hope so.

Why do you need it?

For a start, let’s see why this postcourse therapy is needed? Well, firstly (and this is obvious), the introduction of exogenous hormones leads to an imbalance in the body, the existence of which is not very comfortable. The body, of course, is to a certain extent a self-regulating system, but it would be nice to help it, without waiting for it to cope with the task. Secondly (and this doesn’t seem so obvious anymore), the PCT can help preserve the “earned by overwork” – that is, the muscle mass gained during the course. Well, in the event that, except for water retention, you managed to collect something. Why does this “second” thing not seem so obvious to me? To do this, we need to turn to the queen of sciences – mathematics. Suppose your course consisted of 500 mg of testosterone enanthate per week (I do not consider smaller numbers, because I believe that only a very small number of people can count on a serious return from, say, 250 mg of testosterone enanthate per week). So, we have 500 mg of testosterone enanthate per week. Enanthate ether weighs about 150 mg of these 500, that is, 350 mg remains of pure testosterone. If we take the half-life of enanthate in a week, we get 175 mg of testosterone. Remember the number? Now let’s calculate how much testosterone a week is “worked out” by the average man. The normal daily secretion range is from 4 to 9 mg. We take the upper indicator (although nowadays poor ecology and unimportant general health of the population are clearly not the most common indicator), multiply by 7 (the number of days per week) and we get 63 mg. Well, what do you think, dear readers, will you be able to keep the typed amount of 175 for 63 mg? The question, in my opinion, is rhetorical … Of course, such a calculation is not very correct, but it reflects the big picture quite accurately. However, 63 mg is definitely more than nothing …

When and where to start?

As you know, the best treatment is prevention, so you need to start with it. For this I can offer two solutions that seem to me quite logical and reasonable: firstly, any course containing drugs with progestogenic activity, accompanied by parallel administration of drugs based on cabergoline (dostinex, agalates, bergolak). This will definitely protect against unwanted side effects associated with prolactin and facilitate recovery from the course. It is enough to take half a tablet 2 times a week. And secondly – if you use drugs that significantly reduce the level of endogenous testosterone (I will not give the list – it will be very long), do every second week of the course 2 injections of gonadotropin, 500 IU each. This will help to avoid dystrophy of the testicles, and the recovery of testosterone after the course will be more fun. I would especially recommend it to those athletes who have plans to continue the race – although there are no confirmed cases of sterility from AAS, restoring normal spermatogenesis after several years of using steroids is a difficult task for many people and takes a lot of time – for example, it took the author it’s about six months in this situation. And this is still a good result. Well, let us turn finally to the FCT itself – how much one can walk “around and about”. I do not know about you, readers, but it seems to me that recovery will begin only when the number of exogenous steroids in the body is small enough. There are two options here – if your course was built solely on “long-playing” broadcasts, you will have to wait a period of time – say, two weeks, after which it makes sense to start a PCT. The option is definitely not the most successful – during these two weeks, the level of catabolic hormones will increase rapidly. Therefore, it is more logical to finish the course on preparations with short esters, then after a couple of days you can begin the recovery. Ideally, if you don’t want to move by touch, so to speak, it’s better to pass some tests and to carry out appropriate recovery measures based on them.

Here is a list of them:

  • Lg;
  • FSH;
  • estradiol;
  • prolactin;
  • cortisol.

But, unfortunately, our whole life is far from ideal and to someone the same analyzes can simply be not available for one reason or another. In this case, you do not need to be a clairvoyant or hereditary magician to claim that after the course of LH and FSH, you will be lowered, and the rest of the indicators from the list are higher than the established reference values. Our task is to achieve their normalization. In fact, this task can be divided into two: restoration of normal testosterone levels and cortisol reduction. Restoration of normal testosterone levels. The task, in fact, is not so trivial enough often – as you know, testosterone secretion is controlled by the HH axis – hypothalamus – pituitary – testicles and suppression can occur at all levels. In the most favorable case, when suppression at the level of the hypothalamus is not pronounced, it is enough to lower the level of estrogen and testosterone secretion, which is regulated by feedback, will increase. Here, either anti-estrogens are applicable, or their combination with aromatase inhibitors. As for specific recommendations, if they are antiestrogens, then either tamoxifen, 20-40 mg per day, or Clomid, 100-150 mg per day. In addition to blocking the action of estradiol, antiestrogens promote the secretion of LH by the pituitary gland. Adding IA to them is usually not so necessary, but if the level of estrogen goes off scale, they will not be superfluous here. Of the aromatase inhibitors, exemestane (aromazine) is preferable – it has fewer side effects compared to “classmates” and its activity does not decrease when used together with antiestrogens. The only point that I would like to draw attention to is that if arimidex or letrozole was used on the course, aromazine for some unknown reason does not work after them. If you have taken cabergoline throughout the course with progestogens, you should have no problems with prolactin. Although in a small percentage of men, even the administration of exogenous testosterone can lead to an increase in prolactin. It will help all the same cabergoline.

Avoiding hormonal “pits” and not falling in the eyes of the beautiful half of humanity during recovery can help Proviron, although with prolonged use it can reduce testosterone, since it is in fact an oral form of dihydrotestosterone. He can also reduce the level of SHBG. The use of gonadotropin after the course can be justified with long courses with significant dosages of strong androgens – in such cases, the suppression of testosterone deep and tropic regulation based on the feedback principle may not work. That is, a decrease in estrogen alone will not lead to an increase in testosterone. In this case, it is worth resorting to injection of gonadotropin 1000 IU every other day for 10-14 days at the very beginning of the PCT. This is with regard to pharmaceutical preparations, but preparations from the arsenal of sports nutrition can also help us. Tribulus, which for a long time was almost an obligatory attribute of PCT, according to the results of all modern studies, does not affect the level of PH, but can only increase the level of DHT, which proiron is much better able to handle. He was replaced by D-aspartic acid (especially its methylated version) as a headliner. According to research results, D-aspartic acid, when taken in an amount of 3 grams per day, increased testosterone levels by 42% in 12 days of intake. This, or slightly larger dosage, and should be taken on the PCT. Vitamin and mineral complexes will help us in our difficult work. But it’s worth mentioning one mineral – zinc regulates the amount of androgen receptors in the body, with its deficiency the level of testosterone drops. It is better to take it as part of an additive called ZMA – the combination of zinc with magnesium and vitamin B6 allows it to be better absorbed.